My two cents worth. Yes, you need “enough” room to remove the anode from the top AND the proper socket, breaker bar etc. I have never done this in any water heater. People rarely do. My guestimate is that I wouldn’t mess with it for at least 3 – 5 years unless you are very consciencious.
Also some area codes require the water heater to be XX inches above the floor. In coded areas these stands are purchased from plumbing houses etc, or built.